Trying to lose weight can be a challenge at the best of time, but this challenge may be even harder if you'as regards female. According to an additional laboratory analysis, women's brains may be wired in a habit that makes them less likely than men to shed the pounds.
Published in the journal Molecular Metabolism, the laboratory analysis found that brain cells, or neurons, that fabricate a hormone that regulates body weight performed differently in female mice than in male mice, making female mice less likely to lose weight.
Co-lead scholarly Prof. Lora Heisler, of the Rowett Institute of Nutrition and Health at the University of Aberdeen in the UK, and colleagues publication their findings tilt toward that treatment for obesity should differ by sex.
"Currently there is no difference in how obesity is treated in men and women," explanation Prof. Heisler. "However, what we have discovered is that the portion of the brain that has a significant have an effect on in report to the subject of how we use the calories that we eat is wired differently in males and females."
To achieve their findings, the team - including researchers from the University of Michigan and the UK's University of Cambridge - used obese male and female mouse models that lacked a hormone called proopiomelanocortin (POMC) peptides.
Produced by the brain, POMC peptides entertain a key role in the regulation of appetite, vigor expenditure - the burn of dietary calories - beast vibrancy and overall body weight.
"These POMC neurons so make a earsplitting try for obesity treatment and are, in reality, an important try of an obesity medication used in the USA today," remarks co-guide moot Dr. Luke Burke, moreover of the Rowett Institute of Nutrition and Health.
With this in mind, the team gave the mice obesity medication called lorcaserin, which stimulates the production of POMC peptides.
POMC peptides led to limited weight loss for female mice
As a consequences of the treatment, the obese male mice experienced significant weight loss that pushed their weight into the healthy range. While the female mice drifting some weight, they remained in the obese range.
The team found that this was due to the rotate effects of the POMC peptides in the brains of male and female mice; the obesity medication was found to reduce appetite in both groups, but it on your own helped modulate innate sentient and cartoon expenditure in the male mice.
"In female mice, this source of POMC peptides does not strongly modulate mammal computer graphics or computer graphics expenditure," comments Prof. Heisler. "So, though medications targeting this source of POMC peptides may effectively reduce appetite in females, our evidence suggests that they will not tap into the signals in our brain that modulate creature outrage and energy expenditure."
Obesity is a growing health millstone across the globe. According to the World Health Organization (WHO), difficult than 600 million adults across the globe were obese in 2014, and the rate of worldwide obesity has more than doubled by now 1980.
The researchers note that identifying subsidiary strategies to speak to the obesity epidemic is crucial, and they appointment these uncharacteristic findings could in sustain.
Prof. Heisler adds:
"This psychotherapy reveals that a sex difference in innate objection, animatronics expenditure and body weight is driven by a specific source of brain POMC peptides. This could have broad implications for medications used to fighting obesity, which at power largely ignore the sex of the individual."
Last month, Medical News Today reported upon a psychotherapy that suggests training our taste buds to become more sore spot to the taste of fat could to the fore happening battle obesity.
Published in the journal Molecular Metabolism, the laboratory analysis found that brain cells, or neurons, that fabricate a hormone that regulates body weight performed differently in female mice than in male mice, making female mice less likely to lose weight.
Co-lead scholarly Prof. Lora Heisler, of the Rowett Institute of Nutrition and Health at the University of Aberdeen in the UK, and colleagues publication their findings tilt toward that treatment for obesity should differ by sex.
"Currently there is no difference in how obesity is treated in men and women," explanation Prof. Heisler. "However, what we have discovered is that the portion of the brain that has a significant have an effect on in report to the subject of how we use the calories that we eat is wired differently in males and females."
To achieve their findings, the team - including researchers from the University of Michigan and the UK's University of Cambridge - used obese male and female mouse models that lacked a hormone called proopiomelanocortin (POMC) peptides.
Produced by the brain, POMC peptides entertain a key role in the regulation of appetite, vigor expenditure - the burn of dietary calories - beast vibrancy and overall body weight.
"These POMC neurons so make a earsplitting try for obesity treatment and are, in reality, an important try of an obesity medication used in the USA today," remarks co-guide moot Dr. Luke Burke, moreover of the Rowett Institute of Nutrition and Health.
With this in mind, the team gave the mice obesity medication called lorcaserin, which stimulates the production of POMC peptides.
POMC peptides led to limited weight loss for female mice
As a consequences of the treatment, the obese male mice experienced significant weight loss that pushed their weight into the healthy range. While the female mice drifting some weight, they remained in the obese range.
The team found that this was due to the rotate effects of the POMC peptides in the brains of male and female mice; the obesity medication was found to reduce appetite in both groups, but it on your own helped modulate innate sentient and cartoon expenditure in the male mice.
"In female mice, this source of POMC peptides does not strongly modulate mammal computer graphics or computer graphics expenditure," comments Prof. Heisler. "So, though medications targeting this source of POMC peptides may effectively reduce appetite in females, our evidence suggests that they will not tap into the signals in our brain that modulate creature outrage and energy expenditure."
Obesity is a growing health millstone across the globe. According to the World Health Organization (WHO), difficult than 600 million adults across the globe were obese in 2014, and the rate of worldwide obesity has more than doubled by now 1980.
The researchers note that identifying subsidiary strategies to speak to the obesity epidemic is crucial, and they appointment these uncharacteristic findings could in sustain.
Prof. Heisler adds:
"This psychotherapy reveals that a sex difference in innate objection, animatronics expenditure and body weight is driven by a specific source of brain POMC peptides. This could have broad implications for medications used to fighting obesity, which at power largely ignore the sex of the individual."
Last month, Medical News Today reported upon a psychotherapy that suggests training our taste buds to become more sore spot to the taste of fat could to the fore happening battle obesity.
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